Contributed by: filbert Monday, May 14 2007 @ 02:44 PM CST
In an advance toward understanding the contradictory health effects of bioflavonoids, scientists in Tennessee are reporting that these natural components of fruits and vegetables poison a key human enzyme critical for the normal function of DNA.
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In their laboratory study, the researchers showed that bioflavonoids poison topoisomerase II in cultured human cells. This enzyme plays important roles in many critical DNA processes and removes knots and tangles from the genome. The enzyme acts by making a double-stranded cut in DNA, passing another segment of the double helix through the break, and reconnecting the broken strands.